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A-674563 hydrochloride

CAS No.

A-674563 hydrochloride ( A 674563 hydrochloride;A674563 hydrochloride )

Catalog No. M17012 CAS No.

A-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A-674563 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).
  • Description
    A-674563 is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1); increases the efficacy of paclitaxel in a PC-3 xenograft model; enhances the transcription of several chondrocyte marker genes, including Col2a1, Acan and Col11a2, in mouse primary chondrocytes by inhibiting Sox9 degradation through the ubiquitin-proteasome pathway; also suppresses FLT3-ITD positive AML both in vitro and in vivo.
  • Synonyms
    A 674563 hydrochloride;A674563 hydrochloride
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    --
  • Formula Weight
    ——
  • Molecular Formula
    C22H23ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 30 mg/mL
  • SMILES
    ——
  • Chemical Name
    (S)-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.
2. Tei H, et al. Hum Cell. 2015 Jul;28(3):114-21.
3. Wang A, et al. Oncotarget. 2016 May 17;7(20):29131-42.
4. Kobayashi T, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1468-1475.
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